Download Assessing Ocular Toxicology in Laboratory Animals by Mark Vézina B.Sc (auth.), Andrea B Weir, Margaret Collins PDF

By Mark Vézina B.Sc (auth.), Andrea B Weir, Margaret Collins (eds.)

ISBN-10: 1627031634

ISBN-13: 9781627031639

Ocular toxicity is often assessed in toxicology reviews carried out for regulatory reasons. Ocular anatomy and body structure and the review of ocular toxicity itself may be tough to scientists interested by the protection evaluate of prescribed drugs, insecticides and different brokers. Anatomical and physiological adjustments among species can effect the character of ocular results saw following meant or accidental publicity of ocular tissues to xenobiotics. Ocular Toxicity in Laboratory Animals presents a concise reference addressing ocular anatomy and body structure throughout species that would increase the layout and interpretation of toxicology reports performed for regulatory reasons.

The booklet presents an summary of regimen and complex thoughts which are used to evaluate ocular toxicity together with slit lamp biomicroscopy, oblique ophthalmoscopy, electrophysiology and imaging equipment for the anterior and posterior segments of the attention. also, the e-book defines the regulatory expectancies for prescription drugs meant to regard ocular illnesses and for different non-pharmaceutical regulated chemical substances. With contributions from specialists within the box, Ocular Toxicity in Laboratory Animals is an authoritative, available consultant for toxicologists and different scientists concerned with engaging in toxicology reviews for regulatory reasons and/or reviewing facts from such studies.

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7 H&E histology section of the foveal pit of a cynomolgus monkey Fig. 8 Examples of the relative positions of the optic nerve head (ONH) and area centralis/visual streak (dark regions). (a) Human and nonhuman primate, (b) dog [42], (c) minipig [11, 21], and (d) rabbit [28]; Of note, the foraging/hunting species have a more centrally located concentration of cones while the low to the ground rabbit, a prey animal, is primarily concerned with predators approaching from above and has the region of higher visual acuity arranged as such.

2003;43(6):723–8. 53. Shafiee A, McIntire GL, Sidebotham LC, Ward KW. Experimental determination and allometric prediction of vitreous volume and retina and lens weights in Göttingen minipigs. Vet Ophthalmol. 2008;11:193–6. 54. Shiratani T, Shimizu K, Fujisawa K, Uga S, Nagano K, Murakami Y. Crystalline lens changes in porcine eyes with implanted phakic IOL (ICL) with a central hole. Graefes Arch Clin Exp Ophth. 2008;246(5):719–28. 55. Slatter DH. Cornea and sclera: Chapter 91. In: Textbook of small animal surgery.

Cornea and sclera: Chapter 91. In: Textbook of small animal surgery. 2nd ed. Philadelphia: WB Saunders; 1993. 56. Slatter D. Fundamentals of veterinary ophthalmology. 3rd ed. Philadelphia: WB Saunders; 2001. 57. Solomon IS. Aqueous humor dynamics. 2002. The New York Eye and Ear Infirmary Online. pdf. Accessed 1 Mar 2012. 58. Swarbrick HA et al. IOVS 35: ARVO Abstract No. 1690; 1994. 59. Toshida H, Nguyen D, Beuerman R, Murakami A. Neurologic evaluation of acute lacrimomimetic effect of cyclosporine in an experimental rabbit dry eye model.

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