Download Animal clinical chemistry : a primer for toxicologists by G.O. Evans PDF

By G.O. Evans

ISBN-10: 020336256X

ISBN-13: 9780203362563

By means of providing historical past info at the choice and alertness of biochemical assessments in security evaluate reviews, this advisor seeks to supply a foundation for making improvements to the information required to intepret data.


featuring info at the choice and alertness of biochemical checks in safeguard evaluate reviews, seeks to supply a foundation for bettering the information required to interpret info from Read more...

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Example text

Amongst the tests required by regulatory authorities discussed in Chapter 2 were gamma glutamyl transpeptidase (GGT) and total bilirubin. In most rats, plasma GGT activity is very low (usually <3 IU/L) and plasma bilirubin values are in the range 0–4 µmol/l. In many studies there are no significant changes of these two plasma analytes, although both of these parameters may change with hepatotoxicity (Chapter 6). As both of these measurements are often made where the method is imprecise and at the limits of sensitivity for the assays, small changes of absorbance can result in apparent effects on the plasma levels: plasma GGT may change from 1 to 3 IU/L and similar changes may occur for plasma bilibrubin.

1993) Evaluation of evacuated blood-collection tubes: effects of three types of polymeric separators on therapeutic drug monitoring specimens. Clinical Chemistry, 39, 1712–17. LETELLIER, G. & DESJARLAIS, F. (1985a) Analytical interference of drugs in clinical chemistry: 1. Study of twenty drugs on seven different instruments. Clinical Biochemistry, 18, 345–51. (1985b) Analytical interference of drugs in clinical chemistry: II. The interference of three cephalosporins with the determination of serum creatinine concentration by the Jaffe reaction.

1985) A comparison of 24-hour urine output in male and female mice and rats. Laboratory Animal Science, 35, 546–7. P. L. (1977) Variations of sodium, potassium and chloride plasma levels in the rat with age and sex. Laboratory Animal Science, 27, 972–5. ,TAKESUE, H. & NISHIYAMA, S. (1983) Difference in urinary N-acetyl-beta-D-glucosaminidase activity between male and female beagle dogs. Renal Physiology (Basel), 6, 130–3. N. & IRONS, R. (1985) Effect of sampling site and collection method on variations in baseline clinical pathology parameters in Fischer 344 rats.

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