By G.O. Evans
By means of providing historical past info at the choice and alertness of biochemical assessments in security evaluate reviews, this advisor seeks to supply a foundation for making improvements to the information required to intepret data.
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Additional info for Animal clinical chemistry : a primer for toxicologists
Amongst the tests required by regulatory authorities discussed in Chapter 2 were gamma glutamyl transpeptidase (GGT) and total bilirubin. In most rats, plasma GGT activity is very low (usually <3 IU/L) and plasma bilirubin values are in the range 0–4 µmol/l. In many studies there are no significant changes of these two plasma analytes, although both of these parameters may change with hepatotoxicity (Chapter 6). As both of these measurements are often made where the method is imprecise and at the limits of sensitivity for the assays, small changes of absorbance can result in apparent effects on the plasma levels: plasma GGT may change from 1 to 3 IU/L and similar changes may occur for plasma bilibrubin.
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1985) A comparison of 24-hour urine output in male and female mice and rats. Laboratory Animal Science, 35, 546–7. P. L. (1977) Variations of sodium, potassium and chloride plasma levels in the rat with age and sex. Laboratory Animal Science, 27, 972–5. ,TAKESUE, H. & NISHIYAMA, S. (1983) Difference in urinary N-acetyl-beta-D-glucosaminidase activity between male and female beagle dogs. Renal Physiology (Basel), 6, 130–3. N. & IRONS, R. (1985) Effect of sampling site and collection method on variations in baseline clinical pathology parameters in Fischer 344 rats.