Download An introduction to immunotoxicology by Jacques Descotes PDF

By Jacques Descotes

ISBN-10: 0203362543

ISBN-13: 9780203362549

This article offers a concise and complete creation to key immunotoxicological matters for all these drawn to, yet without past wisdom of, this region of toxicology. the 1st part explores the healthiness outcomes of immunotoxicity, specifically the adversarial results with regards to chemically-induced immunosuppression and immunostimulation, allergy reactions and autoimmune ailments, with an summary of significant immunotoxicants. the second one half describes the most recent tools used to notice and evaluation, preclinically and clinically, the unforeseen immunotoxic results of xenobiotics. tendencies in enforcing concepts and up to date alterations to the regulatory elements also are thought of. The 3rd part examines attainable destiny advancements, together with In Vitro tools, biomarkers of immunotixicity and threat evaluate.

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Example text

Finally, allergies or sensitivities in relation to environmental exposures have been claimed to affect a significant fraction of the general population, although a reliable diagnosis is very difficult to obtain in most cases of multiple chemical sensitivity syndrome (Miller, 1996). A major problem when dealing with hypersensitivity reactions induced by xenobiotics is the current lack of clear understanding of the mechanism or most certainly mechanisms involved in so many instances. A number of reactions have been considered to be immunemediated (that is to say the consequence of immunological response), but in fact not all are unequivocally antigen-specific (DeSwarte, 1986; Wedner, 1987).

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London: Current Biology Ltd, Garland Publishing. , et al. (1994) Acute-phase response, interleukin-6, and alteration of cyclosporine pharmacokinetics. Clin. Pharmacol. , 55, 649–660. S. L. (1995) Experimental basis for neural-immune interactions. Physiol. , 75, 77–106. MAES, M. (1995) Evidence for an immune response in major depression: a review and hypothesis. Prog. Neuro-Psychopharmacol. , 19, 11–38. S. (1993) Exercise and immunology. Med. Sci. , 26, 125–127. E. (1993) Fundamental Immunology, 3rd edition.

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