By George Stouffer
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Additional resources for Adverse Drug Interactions - A Handbook for Prescribers
It relates to the effects that occur during absorption (which can also be adjusted by manipulating certain pharmaceutical properties), distribution, metabolism and excretion. Pharmacokinetic interactions result in changes in the concentration of the drug at its site of action. Absorption can be affected by changes to the transport proteins in the intestine (see the section on ‘Transport proteins’ below), due to drugs binding (chelating) with other drugs in the gut lumen, alterations of pH within the gut (particularly within the stomach) or alterations in gastrointestinal motility.
Cardiovascular drugs Antiarrhythmics procaine 498, 501, 502 9. Anaesthetic drugs Anaesthetics – local procarbazine 334–338 3. Anticancer and immunomodulating drugs Cytotoxics prochlorperazine 261 2. Drugs acting on the nervous system Antipsychotics procyclidine 241 progesterones 662–663 2. Drugs acting on the nervous system 14. Drugs used in obstetrics and gynaecology AntiParkinson’s drugs Female hormones proguanil 587–588 10. Drugs to treat infections Antimalarials promazine 12. Respiratory drugs 1.
An essential preliminary step to prevent adverse drug–drug interactions is to obtain a comprehensive list of medications that a patient is taking. Unfortunately, there may be difficulties in taking an accurate drug history, often due to lack of time and especially when patients also take traditional/natural remedies, OTC drugs and nutrients, which patients often consider as unimportant to reveal. This book, written with a definite clinical bias (as the editors and contributors are practising prescribers from a range of disciplines), is designed to be an easily accessible reference for busy prescribers/dispensers who may not have access to, or the time to search, the more comprehensive resources on adverse drug–drug interactions both in print and online.